Is Alpha-Synuclein in the Colon a Biomarker for Premotor Parkinson's Disease? Evidence from 3 Cases
Identifieur interne : 001081 ( Main/Exploration ); précédent : 001080; suivant : 001082Is Alpha-Synuclein in the Colon a Biomarker for Premotor Parkinson's Disease? Evidence from 3 Cases
Auteurs : Kathleen M. Shannon [États-Unis] ; Ali Keshavarzian [États-Unis] ; Hemraj B. Dodiya [États-Unis] ; Shriram Jakate [États-Unis] ; Jeffrey H. Kordower [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Despite clinicopathological evidence that Parkinson's disease (PD) may begin in peripheral tissues, identification of premotor Parkinson's disease is not yet possible. Alpha-synuclein aggregation underlies Parkinson's disease pathology, and its presence in peripheral tissues may be a reliable disease biomarker. Objective: We sought evidence of alpha-synuclein pathology in colonic tissues before the development of characteristic Parkinson's disease motor symptoms. Methods: Old colon biopsy samples were available for three subjects with PD. Biopsies were obtained 2-5 years before PD onset. We performed immunohistochemistry studies for the presence of alpha-synuclein and Substance P in these samples. Results: All subjects showed immunostaining for alpha-synuclein (two, five and two years before first motor Parkinson's disease symptom). No similar alpha-synuclein immunostaining was seen in 23 healthy controls. Staining of samples for substance P suggested colocalization of alpha-synuclein and substance P in perikarya and neurites. Conclusions: This is the first demonstration of alpha-synuclein in colon tissue prior to onset of PD. Additional study is required to determine whether colonic mucosal biopsy may be a biomarker of premotor PD.
Affiliations:
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Shannon</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, Rush Medical College</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Keshavarzian, Ali" sort="Keshavarzian, Ali" uniqKey="Keshavarzian A" first="Ali" last="Keshavarzian">Ali Keshavarzian</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Gastroenterology and Nutrition, Rush Medical College</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Dodiya, Hemraj B" sort="Dodiya, Hemraj B" uniqKey="Dodiya H" first="Hemraj B." last="Dodiya">Hemraj B. 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Evidence from 3 Cases</title><author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M." last="Shannon">Kathleen M. Shannon</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, Rush Medical College</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Keshavarzian, Ali" sort="Keshavarzian, Ali" uniqKey="Keshavarzian A" first="Ali" last="Keshavarzian">Ali Keshavarzian</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Gastroenterology and Nutrition, Rush Medical College</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Dodiya, Hemraj B" sort="Dodiya, Hemraj B" uniqKey="Dodiya H" first="Hemraj B." last="Dodiya">Hemraj B. Dodiya</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Center for Brain Repair, Rush Medical College</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Jakate, Shriram" sort="Jakate, Shriram" uniqKey="Jakate S" first="Shriram" last="Jakate">Shriram Jakate</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Pathology, Rush Medical College</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H." last="Kordower">Jeffrey H. Kordower</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Center for Brain Repair, Rush Medical College</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Colon</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Substance P</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Côlon</term><term>Substance P</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Despite clinicopathological evidence that Parkinson's disease (PD) may begin in peripheral tissues, identification of premotor Parkinson's disease is not yet possible. Alpha-synuclein aggregation underlies Parkinson's disease pathology, and its presence in peripheral tissues may be a reliable disease biomarker. Objective: We sought evidence of alpha-synuclein pathology in colonic tissues before the development of characteristic Parkinson's disease motor symptoms. Methods: Old colon biopsy samples were available for three subjects with PD. Biopsies were obtained 2-5 years before PD onset. We performed immunohistochemistry studies for the presence of alpha-synuclein and Substance P in these samples. Results: All subjects showed immunostaining for alpha-synuclein (two, five and two years before first motor Parkinson's disease symptom). No similar alpha-synuclein immunostaining was seen in 23 healthy controls. Staining of samples for substance P suggested colocalization of alpha-synuclein and substance P in perikarya and neurites. Conclusions: This is the first demonstration of alpha-synuclein in colon tissue prior to onset of PD. Additional study is required to determine whether colonic mucosal biopsy may be a biomarker of premotor PD.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M." last="Shannon">Kathleen M. Shannon</name></region><name sortKey="Dodiya, Hemraj B" sort="Dodiya, Hemraj B" uniqKey="Dodiya H" first="Hemraj B." last="Dodiya">Hemraj B. Dodiya</name><name sortKey="Jakate, Shriram" sort="Jakate, Shriram" uniqKey="Jakate S" first="Shriram" last="Jakate">Shriram Jakate</name><name sortKey="Keshavarzian, Ali" sort="Keshavarzian, Ali" uniqKey="Keshavarzian A" first="Ali" last="Keshavarzian">Ali Keshavarzian</name><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H." last="Kordower">Jeffrey H. 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